Anti-Human INPPL1 Polyclonal Antibody|抗人INPPL1多克隆抗体(靶标：人肌醇多磷酸磷酸酶样1/SHIP2)
- 货号：RB9THD553014
- 价格：面议
- 点击：449
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Human, Rat, Mouse |
| 靶标 | EC:3.1.3.86, INPPL-1, INPPL1, Inositol polyphosphate phosphatase-like protein 1, Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2, Protein 51C, SH2 domain-containing inositol 5'-phosphatase 2, |
| 免疫原 | E. coli - derived recombinant Human INPPL1 (Asp422-Thr730). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | O15357 |
| 背景信息 | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (INPPL1) is a ~138 kDa protein. Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Required for correct mitotic spindle orientation and therefore progression of mitosis. Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear. While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling or GLUT4 trafficking. Confers resistance to dietary obesity. 1. Vandeput, F. et al. (2006) Cellular signalling 18, 2193-9. PMID: 16824732 2. Habib, T. et al. (1998) The Journal of biological chemistry 273, 18605-9. PMID: 9660833 3. Dyson, JM. et al. (2001) The Journal of cell biology 155, 1065-79. PMID: 11739414 4. Dyson, JM. et al. (2003) Blood 102, 940-8. PMID: 12676785 5. Prasad, NK. et al. (2005) The Journal of biological chemistry 280, 13129-36. PMID: 15668240 6. Hasegawa, J. et al. (2011) The Journal of cell biology 193, 901-16. PMID: 21624956 7. Prasad, N. et al. (2002) Journal of cell science 115, 3807-15. PMID: 12235291 8. Koch, A. et al. (2005) Oncogene 24, 3436-47. PMID: 15735664 9. Zhuang, G. et al. (2007) The Journal of biological chemistry 282, 2683-94. PMID: 17135240 10. Pengal, RA. et al. (2003) The Journal of biological chemistry 278, 22657-63. PMID: 12690104 |
| 备注 | For research use only |
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