Anti-Human GPR15LG Polyclonal Antibody|抗人GPR15LG多克隆抗体(靶标：人GPR15配体)
- 货号：RB9THD559014
- 价格：面议
- 点击：378
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Homo sapiens (Human) |
| 靶标 | AP-57, Antimicrobial peptide with 57 amino acid residues, Antimicrobial peptide-57, C10orf99, CSBF, Colon-derived SUSD2 binding factor, GPR15L, GPR15LG, Protein GPR15 ligand, Protein GPR15L, Protein G |
| 免疫原 | E. coli - derived recombinant Human GPR15LG (Lys25-Val82). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | Q6UWK7 |
| 背景信息 | Protein GPR15LG is a ~9 kDa protein. Highly cationic protein that has multiple functions. Acts as a chemotactic factor that mediates lymphocytes recruitment to epithelia through binding and activation of the G-protein coupled receptor GPR15. May be a tumor suppressor; together with SUSD2 has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest. May regulate keratinocyte proliferation. In addition, through activation of Mas-related G protein-coupled receptors (MRGPRs) contributes to pruritogenesis by activating itch-selective sensory neurons and mast cells degranulation. 1. Suply, T. et al. (2017) Science signaling 10. PMID: 28900043 2. Ocón, B. et al. (2017) Frontiers in immunology 8, 1111. PMID: 28936214 3. Pan, W. et al. (2014) Scientific reports 4, 6812. PMID: 25351403 4. Chen, C. et al. (2018) Scientific reports 8, 8590. PMID: 29872130 5. Tseng, PY. et al. (2022) Science advances 8, eabm7342. PMID: 35704588 |
| 备注 | For research use only |
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