Anti-Human CYLD Polyclonal Antibody|抗人CYLD多克隆抗体(靶标：人CYLD去泛素酶)
- 货号：RB9THV742014
- 价格：面议
- 点击：441
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Rat, Human, Mouse |
| 靶标 | CYLD, CYLD1, Deubiquitinating enzyme CYLD, EC:3.4.19.12, KIAA0849, Ubiquitin carboxyl-terminal hydrolase CYLD, Ubiquitin thioesterase CYLD, Ubiquitin-specific-processing protease CYLD |
| 免疫原 | E. coli - derived recombinant Human CYLD (Asn553-Lys956). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | Q9NQC7 |
| 背景信息 | Ubiquitin carboxyl-terminal hydrolase CYLD is a ~107 kDa protein. Deubiquitinase that specifically cleaves 'Lys-63'- and linear 'Met-1'-linked polyubiquitin chains and is involved in NF-kappa-B activation and TNF-induced necroptosis. Negatively regulates NF-kappa-B activation by deubiquitinating upstream signaling factors. Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation. Negative regulator of Wnt signaling. Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules. 1. Komander, D. et al. (2008) Molecular cell 29, 451-64. PMID: 18313383 2. Friedman, CS. et al. (2008) EMBO reports 9, 930-6. PMID: 18636086 3. Draber, P. et al. (2015) Cell reports 13, 2258-72. PMID: 26670046 4. Hrdinka, M. et al. (2016) Cell reports 14, 2846-58. PMID: 26997266 5. Schlicher, L. et al. (2016) EMBO reports 17, 1485-1497. PMID: 27458237 6. Elliott, PR. et al. (2016) Molecular cell 63, 990-1005. PMID: 27591049 7. Ohtake, F. et al. (2016) Molecular cell 64, 251-266. PMID: 27746020 8. Ji, YX. et al. (2018) Nature medicine 24, 213-223. PMID: 29291351 9. Dobson-Stone, C. et al. (2020) Brain : a journal of neurology 143, 783-799. PMID: 32185393 10. Trompouki, E. et al. (2003) Nature 424, 793-6. PMID: 12917689 |
| 备注 | For research use only |
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