Anti-Human C9orf72 Polyclonal Antibody|抗人C9orf72多克隆抗体(靶标：人9号染色体开放阅读框72蛋白)
- 货号：RB9THA376014
- 价格：面议
- 点击：521
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Mouse, Rat, Human |
| 靶标 | C9orf72, DENND9, DENNL72, Guanine nucleotide exchange factor C9orf72 |
| 免疫原 | E. coli - derived recombinant Human C9orf72 (Met1-Asn222). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | Q96LT7 |
| 背景信息 | Guanine nucleotide exchange factor C9orf72 is a ~54 kDa protein. Acts as a guanine-nucleotide releasing factor (GEF) for Rab GTPases by promoting the conversion of inactive RAB-GDP to the active form RAB-GTP. Acts as a GEF for RAB39A which enables HOPS-mediated autophagosome-lysosome membrane tethering and fusion in mammalian autophagy. Component of the C9orf72-SMCR8 complex where both subunits display GEF activity and that regulates autophagy. As part of the C9orf72-SMCR8-WDR41 (CSW) complex, functions as GEF for RAB8A and RAB39B, thereby promoting autophagosome maturation. As part of the C9orf72-SMCR8 complex, also functions as GTPase activating protein (GAP) for RAB8A and RAB11A in vitro. 1. Sellier, C. et al. (2016) The EMBO journal 35, 1276-97. PMID: 27103069 2. Sullivan, PM. et al. (2016) Acta neuropathologica communications 4, 51. PMID: 27193190 3. Yang, M. et al. (2016) Science advances 2, e1601167. PMID: 27617292 4. Jung, J. et al. (2017) eLife 6. PMID: 28195531 5. Zhang, S. et al. (2023) Nature communications 14, 6360. PMID: 37821429 |
| 备注 | For research use only |
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