| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Mouse, Human |
| 靶标 | 17-beta-hydroxysteroid dehydrogenase, 3-beta-hydroxysteroid 3-dehydrogenase, DHRS11, Dehydrogenase/reductase SDR family member 11, EC:1.1.1.270, EC:1.1.1.62, Estradiol 17-beta-dehydrogenase, SDR24C1, |
| 免疫原 | E. coli - derived recombinant Human DHRS11 (Leu31-Thr260). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | Q6UWP2 |
| 背景信息 | Dehydrogenase/reductase SDR family member 11 (DHRS11) is a ~28 kDa protein. Catalyzes the conversion of the 17-keto group of estrone, 4- and 5-androstenes and 5-alpha-androstanes into their 17-beta-hydroxyl metabolites and the conversion of the 3-keto group of 3-, 3,17- and 3,20- diketosteroids into their 3beta-hydroxyl metabolites. Exhibits reductive 3-beta-hydroxysteroid dehydrogenase activity toward 5-beta-androstanes, 5-beta-pregnanes, 4-pregnenes and bile acids. May contribute to the metabolism of adrenal-derived androgen precursors. Reduces 11-keto-4-androstene-3,17-dione (11KA4) and 11-keto-5alpha-androstane-3,17-dione (11K-Adione) into potent androgens 11-ketotestosterone (11KT) and 11-ketodihydrotestosterone (11KDHT), respectively. May also reduce endogenous and exogenous alpha-dicarbonyl compounds and xenobiotic alicyclic ketones. 1. Endo, S. et al. (2016) Biochemical and biophysical research communications 472, 231-6. PMID: 26920053 2. Endo, S. et al. (2020) The Journal of steroid biochemistry and molecular biology 199, 105586. PMID: 31926269 |
| 备注 | For research use only |
| 产品名称 | 点击数 |
|---|---|
| 氯丙嗪单抗 | 5722 |
| 西马特罗单抗 | 5702 |
| 孕酮单抗 | 5896 |
| 氯霉素(CAP)单抗 | 5834 |
| 红霉素单抗 | 5812 |
| 地克珠利单抗 | 5610 |
| 无色孔雀石绿(LMG)单抗 | 5835 |
| 雌二醇单抗 | 5458 |
| 孔雀石绿(MG)单抗 | 5988 |
| 双酚A单抗 | 5761 |
| 呋喃妥因代谢物(2-NPAHD)单抗 | 5630 |
| 己烯雌酚单抗 | 5641 |
| 莱克多巴胺(RAC)单抗 | 5800 |
| 林可霉素单抗 | 6001 |
| 抗青霉素受体单抗 | 5633 |
| 大观霉素单抗 | 5692 |
| 克伦特罗(CL)单抗 | 5913 |
| 沙拉沙星单抗(2H4) | 5724 |
| 磺胺对甲氧嘧啶(SMD)单抗 | 5896 |
| 磺胺类SAS单抗 | 5835 |