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Anti-Human KCNA5 Polyclonal Antibody|抗人KCNA5多克隆抗体(靶标:人电压门控钾通道亚家族A成员5/Kv1.5)

  • 货号:RB9THB985014
  • 价格:面议
  • 点击:490

产品介绍

产品参数

形态Liquid
宿主种属Rabbit
克隆性Polyclonal
抗体亚型IgG
纯化方式Purified by antigen affinity column.
内毒素水平Please contact with the lab for this information.
应用ELISA, IHC, WB
种属反应性Human, Rat, Mouse
靶标HPCN1, KCNA5, Potassium voltage-gated channel subfamily A member 5, Voltage-gated potassium channel HK2, Voltage-gated potassium channel subunit Kv1.5
免疫原E. coli - derived recombinant Human KCNA5 (Thr106-Gly247).
储存缓冲液0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
产品使用说明ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000
登录号P22460
背景信息

Potassium voltage-gated channel subfamily A member 5 (KCNA5) is a ~67 kDa protein. Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel. Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation.

1. Williams, CP. et al. (2002) The Journal of pharmacology and experimental therapeutics 302, 545-50. PMID: 12130714
2. Snyders, DJ. et al. (1993) The Journal of general physiology 101, 513-43. PMID: 8505626
备注For research use only
【仅供科学研究使用】

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