Anti-Human KDM1A Polyclonal Antibody|抗人KDM1A多克隆抗体(靶标：人赖氨酸去甲基化酶1A/LSD1)
- 货号：RB9THD579014
- 价格：面议
- 点击：193
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Rat, Mouse, Human |
| 靶标 | AOF2, BHC110, BRAF35-HDAC complex protein BHC110, EC:1.14.11.-, EC:1.14.11.65, EC:1.14.99.66, Flavin-containing amine oxidase domain-containing protein 2, KDM1, KDM1A, KIAA0601, LSD1, Lysine-specific |
| 免疫原 | E. coli - derived recombinant Human KDM1A (Arg524-Met852). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | O60341 |
| 背景信息 | Lysine-specific histone demethylase 1A (KDM1A) is a ~92 kDa protein. Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2). May play a role in the repression of neuronal genes. 1. Shi, Y. et al. (2004) Cell 119, 941-53. PMID: 15620353 2. Forneris, F. et al. (2005) FEBS letters 579, 2203-7. PMID: 15811342 3. Lee, MG. et al. (2005) Nature 437, 432-5. PMID: 16079794 4. Metzger, E. et al. (2005) Nature 437, 436-9. PMID: 16079795 5. Shi, YJ. et al. (2005) Molecular cell 19, 857-64. PMID: 16140033 6. Forneris, F. et al. (2005) The Journal of biological chemistry 280, 41360-5. PMID: 16223729 7. Luo, H. et al. (2016) Cell reports 15, 2665-78. PMID: 27292636 10. Lin, Y. et al. (2010) The EMBO journal 29, 1803-16. PMID: 20389281 |
| 备注 | For research use only |
相关产品:
| 产品名称 | 点击数 |
|---|---|
| 空肠弯曲菌单克隆抗体 | 7535 |
| 人触珠蛋白单克隆抗体 | 7743 |
| 贾第鞭毛虫单克隆抗体 | 7386 |
| 阿米巴单克隆抗体 | 7935 |
| 胃蛋白酶单克隆抗体 | 7416 |
| 胃蛋白酶原II单克隆抗体 | 7645 |
| 胃蛋白酶原I单克隆抗体 | 7354 |
| 艰难梭菌毒素A单克隆抗体 | 7511 |
| 艰难梭菌毒素B单克隆抗体 | 7812 |
| 艰难梭菌GDH单克隆抗体 | 7799 |
| 诺如病毒单克隆抗体 | 7290 |
| 伤寒沙门氏菌单克隆抗体 | 7384 |
| 鼠疫耶尔森菌F1单克隆抗体 | 6883 |
| 幽门螺杆菌单克隆抗体 | 7407 |
| 钙卫蛋白单克隆抗体 | 7174 |
| 乳铁蛋白单克隆抗体 | 7539 |
| 转铁蛋白单克隆抗体 | 7542 |
| 血红蛋白单克隆抗体 | 7250 |
| 腺病毒单克隆抗体 | 7473 |
| 轮状病毒单克隆抗体 | 7876 |