Anti-Human TRIM22 Polyclonal Antibody|抗人TRIM22多克隆抗体(靶标：人三联基序蛋白22)
- 货号：RB9THC134014
- 价格：面议
- 点击：591
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Human |
| 靶标 | 50 kDa-stimulated trans-acting factor, E3 ubiquitin-protein ligase TRIM22, EC:2.3.2.27, RING finger protein 94, RING-type E3 ubiquitin transferase TRIM22, RNF94, STAF50, Staf-50, TRIM22, Tripartite mo |
| 免疫原 | E. coli - derived recombinant Human TRIM22 (Ser317-Ser498). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | Q8IYM9 |
| 背景信息 | E3 ubiquitin-protein ligase TRIM22 is a ~56 kDa protein. Interferon-induced E3 ubiquitin ligase that plays important roles in innate and adaptive immunity. Restricts the replication of many viruses including HIV-1, encephalomyocarditis virus (EMCV), hepatitis B virus (HBV), hepatitis C virus (HCV) or Zika virus (ZIKV). Mechanistically, negatively regulates HCV replication by promoting ubiquitination and subsequent degradation of viral NS5A. Also acts by promoting the degradation of Zika virus NS1 and NS3 proteins through proteasomal degradation. Acts as a suppressor of basal HIV-1 LTR-driven transcription by preventing Sp1 binding to the HIV-1 promoter. 1. Yang, C. et al. (2016) Cellular & molecular immunology 13, 94-102. PMID: 25683609 2. Inoue, A. et al. (2022) Biochimica et biophysica acta. Molecular cell research 1869, 119318. PMID: 35777501 3. Zu, S. et al. (2022) Cell & bioscience 12, 139. PMID: 36042495 4. Turrini, F. et al. (2015) Retrovirology 12, 104. PMID: 26683615 5. Fei, X. et al. (2022) Molecular therapy oncolytics 26, 413-428. PMID: 36159777 |
| 备注 | For research use only |
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