Anti-Human SH3RF1 Polyclonal Antibody|抗人SH3RF1多克隆抗体(靶标：人SH3结构域含环指蛋白1)
- 货号：RB9THD618014
- 价格：面议
- 点击：446
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Human, Rat, Mouse |
| 靶标 | E3 ubiquitin-protein ligase SH3RF1, EC:2.3.2.27, KIAA1494, POSH, POSH1, Plenty of SH3s, Protein POSH, RING finger protein 142, RING-type E3 ubiquitin transferase SH3RF1, RNF142, SH3 domain-containing |
| 免疫原 | E. coli - derived recombinant Human SH3RF1 (Gln135-Lys268). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | Q7Z6J0 |
| 背景信息 | E3 ubiquitin-protein ligase SH3RF1 is a ~93 kDa protein. Has E3 ubiquitin-protein ligase activity. In the absence of an external substrate, it can catalyze self-ubiquitination. Stimulates ubiquitination of potassium channel KCNJ1, enhancing its dynamin-dependent and clathrin-independent endocytosis. Acts as a scaffold protein that coordinates with MAPK8IP1/JIP1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the differentiation of CD4(+) and CD8(+) T-cells and promotes T-helper 1 (Th1) cell differentiation. 1. Alroy, I. et al. (2005) Proceedings of the National Academy of Sciences of the United States of America 102, 1478-83. PMID: 15659549 2. Kärkkäinen, S. et al. (2010) FEBS letters 584, 3867-72. PMID: 20696164 3. Lin, DH. et al. (2009) The Journal of biological chemistry 284, 29614-24. PMID: 19710010 |
| 备注 | For research use only |
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