Anti-Human PLCG1 Polyclonal Antibody|抗人PLCG1多克隆抗体(靶标：人磷脂酶Cγ1)
- 货号：RB9THB687014
- 价格：面议
- 点击：352
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Mouse, Human, Rat |
| 靶标 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, EC:3.1.4.11, PLC-148, PLC-II, PLC-gamma-1, PLC1, PLCG1, Phosphoinositide phospholipase C-gamma-1, Phospholipase C-II, Phospholipase C |
| 免疫原 | E. coli - derived recombinant Human PLCG1 (His545-Ile764). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | P19174 |
| 背景信息 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1) is a ~148 kDa protein. Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, EGFR, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration. Guanine nucleotide exchange factor that binds the GTPase DNM1 and catalyzes the dissociation of GDP, allowing a GTP molecule to bind in its place, therefore enhancing DNM1-dependent endocytosis. 1. Wang, Y. et al. (2007) American journal of physiology. Cell physiology 292, C1775-86. PMID: 17229814 |
| 备注 | For research use only |
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