Anti-Human CBX5 Polyclonal Antibody|抗人CBX5多克隆抗体(靶标：人染色盒同源物5/HP1α)
- 货号：RB9THW777024
- 价格：面议
- 点击：404
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Human, Mouse |
| 靶标 | Antigen p25, CBX5, Chromobox protein homolog 5, HP1 alpha, HP1A, Heterochromatin protein 1 homolog alpha |
| 免疫原 | E. coli - derived recombinant Human CBX5 (Tyr20-Ser191). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | P45973 |
| 背景信息 | Chromobox protein homolog 5 (CBX5) is a ~22 kDa protein. Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Also recognizes and binds histone H1.4 methylated at 'Lys-26' (H1.4K26me). Excluded from chromatin when histone H1.4 is Simultaneously methylated at Lys-26 (H1.4K26me) and phosphorylated at Ser-27 (H1.4S27Ph). May contribute to the association of heterochromatin with the inner nuclear membrane by interactions with the lamin-B receptor (LBR). 1. Zhou, L. et al. (2025) Science (New York, N.Y.) 389, 309-316. PMID: 40440427 2. Dawson, MA. et al. (2009) Nature 461, 819-22. PMID: 19783980 3. Daujat, S. et al. (2005) The Journal of biological chemistry 280, 38090-5. PMID: 16127177 4. Kiyomitsu, T. et al. (2010) The Journal of cell biology 188, 791-807. PMID: 20231385 |
| 备注 | For research use only |
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