当前位置：首页>产品中心>单抗/多抗>Anti-Human CD45/PTPRC Polyclonal Antibody|抗人CD45/PTPRC多克隆抗体(靶标：人蛋白酪氨酸磷酸酶受体C型/CD45)
Anti-Human CD45/PTPRC Polyclonal Antibody|抗人CD45/PTPRC多克隆抗体(靶标：人蛋白酪氨酸磷酸酶受体C型/CD45)
- 货号：RB9THY195014
- 价格：面议
- 点击：559
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Human |
| 靶标 | CD45, EC:3.1.3.48, L-CA, Leukocyte common antigen, PTPRC, Receptor-type tyrosine-protein phosphatase C, T200 |
| 免疫原 | E. coli - derived recombinant Human CD45/PTPRC (Thr227-Asn575). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | P08575 |
| 背景信息 | Receptor-type tyrosine-protein phosphatase C (CD45/PTPRC) is a ~147 kDa protein. Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity. 1. Dunlock, VE. et al. (2022) Cell reports 39, 111006. PMID: 35767951 |
| 备注 | For research use only |
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