Anti-Human BACE2 Polyclonal Antibody|抗人BACE2多克隆抗体(靶标：人β-分泌酶2)
- 货号：RB9THV256014
- 价格：面议
- 点击：453
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Mouse, Rat, Human |
| 靶标 | AEPLC, ALP56, ASP1, ASP21, Asp 1, Aspartic-like protease 56 kDa, Aspartyl protease 1, BACE2, Beta-secretase 2, Beta-site APP cleaving enzyme 2, Beta-site amyloid precursor protein cleaving enzyme 2, D |
| 免疫原 | E. coli - derived recombinant Human BACE2 (Phe77-Ser445). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | Q9Y5Z0 |
| 背景信息 | Beta-secretase 2 (BACE2) is a ~56 kDa protein. Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. Involved in the proteolytic shedding of PMEL at early stages of melanosome biogenesis. Cleaves PMEL within the M-beta fragment to release the amyloidogenic PMEL luminal fragment containing M-alpha and a small portion of M-beta N-terminus. 1. Yan, R. et al. (1999) Nature 402, 533-7. PMID: 10591213 2. Hussain, I. et al. (2000) Molecular and cellular neurosciences 16, 609-19. PMID: 11083922 3. Yan, R. et al. (2001) The Journal of biological chemistry 276, 34019-27. PMID: 11423558 4. Sun, X. et al. (2005) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 19, 739-49. PMID: 15857888 5. Sun, X. et al. (2006) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20, 1369-76. PMID: 16816112 6. Rochin, L. et al. (2013) Proceedings of the National Academy of Sciences of the United States of America 110, 10658-63. PMID: 23754390 7. Esterházy, D. et al. (2011) Cell metabolism 14, 365-77. PMID: 21907142 |
| 备注 | For research use only |
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