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Anti-Human GPR37L1 Polyclonal Antibody|抗人GPR37L1多克隆抗体(靶标:人G蛋白偶联受体37样1)

  • 货号:RB9THD416014
  • 价格:面议
  • 点击:212
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产品介绍

产品参数

形态Liquid
宿主种属Rabbit
克隆性Polyclonal
抗体亚型IgG
纯化方式Purified by antigen affinity column.
内毒素水平Please contact with the lab for this information.
应用ELISA, IHC, WB
种属反应性Human
靶标ETBR-LP-2, ETBRLP2, Endothelin B receptor-like protein 2, G-protein coupled receptor 37-like 1, GPR37L1
免疫原E. coli - derived recombinant Human GPR37L1 (Ala26-Met134).
储存缓冲液0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
产品使用说明ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000
登录号O60883
背景信息

G-protein coupled receptor 37-like 1 (GPR37L1) is a ~52 kDa protein. G-protein coupled receptor. Has been shown to bind the neuroprotective and glioprotective factor prosaposin (PSAP), leading to endocytosis followed by an ERK phosphorylation cascade. However, other studies have shown that prosaposin does not increase activity. It has been suggested that GPR37L1 is a constitutively active receptor which signals through the guanine nucleotide-binding protein G(s) subunit alpha. Participates in the regulation of postnatal cerebellar development by modulating the Shh pathway.

1. Coleman, JL. et al. (2016) Science signaling 9, ra36. PMID: 27072655
2. Meyer, RC. et al. (2013) Proceedings of the National Academy of Sciences of the United States of America 110, 9529-34. PMID: 23690594
3. Giddens, MM. et al. (2017) Neurobiology of disease 106, 181-190. PMID: 28688853
备注For research use only
【仅供科学研究使用】

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