Anti-Human GPR37L1 Polyclonal Antibody|抗人GPR37L1多克隆抗体(靶标：人G蛋白偶联受体37样1)
- 货号：RB9THD416014
- 价格：面议
- 点击：360
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Human |
| 靶标 | ETBR-LP-2, ETBRLP2, Endothelin B receptor-like protein 2, G-protein coupled receptor 37-like 1, GPR37L1 |
| 免疫原 | E. coli - derived recombinant Human GPR37L1 (Ala26-Met134). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | O60883 |
| 背景信息 | G-protein coupled receptor 37-like 1 (GPR37L1) is a ~52 kDa protein. G-protein coupled receptor. Has been shown to bind the neuroprotective and glioprotective factor prosaposin (PSAP), leading to endocytosis followed by an ERK phosphorylation cascade. However, other studies have shown that prosaposin does not increase activity. It has been suggested that GPR37L1 is a constitutively active receptor which signals through the guanine nucleotide-binding protein G(s) subunit alpha. Participates in the regulation of postnatal cerebellar development by modulating the Shh pathway. 1. Coleman, JL. et al. (2016) Science signaling 9, ra36. PMID: 27072655 2. Meyer, RC. et al. (2013) Proceedings of the National Academy of Sciences of the United States of America 110, 9529-34. PMID: 23690594 3. Giddens, MM. et al. (2017) Neurobiology of disease 106, 181-190. PMID: 28688853 |
| 备注 | For research use only |
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