当前位置:首页>产品中心>单抗/多抗>Anti-HSV-2/HHV-2 glycoprotein H/gH Polyclonal Antibody|抗HSV-2/HHV-2糖蛋白H/gH多克隆抗体(靶标:单纯疱疹病毒2型包膜糖蛋白H)

Anti-HSV-2/HHV-2 glycoprotein H/gH Polyclonal Antibody|抗HSV-2/HHV-2糖蛋白H/gH多克隆抗体(靶标:单纯疱疹病毒2型包膜糖蛋白H)

  • 货号:RB9TVK081024
  • 价格:面议
  • 点击:447
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产品介绍

产品参数

形态Liquid
宿主种属Rabbit
克隆性Polyclonal
抗体亚型IgG
纯化方式Purified by antigen affinity column.
内毒素水平Please contact with the lab for this information.
应用ELISA, IHC, WB
种属反应性Human herpesvirus 2
靶标Envelope glycoprotein H, gH
免疫原E. coli - derived recombinant HSV-2/HHV-2 glycoprotein H/gH (Arg49-Pro803).
储存缓冲液0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
产品使用说明ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000
登录号P89445
背景信息

Envelope glycoprotein H (gH) is a ~89 kDa protein. The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Following initial binding to host receptor, membrane fusion is mediated by the fusion machinery composed of gB and the heterodimer gH/gL. May also be involved in the fusion between the virion envelope and the outer nuclear membrane during virion morphogenesis. Interaction with host integrins ITGAV/ITGB3 triggers release of cytosolic Ca(2+) and FAK phosphorylation leading to efficient viral entry into host genital tract epithelial cells.

1. Cheshenko, N. et al. (2014) Journal of virology 88, 10026-38. PMID: 24942591
备注For research use only
【仅供科学研究使用】

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