| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Phaeosphaeria nodorum, Sclerotinia sclerotiorum, Aspergillus oryzae, Coccidioides immitis, Glomerella lagenarium, Aspergillus fumigatus, Pyricularia oryzae, Colletotrichum lindemuthianum, Neurospora c |
| 靶标 | ATG8, Autophagy-related protein 8, Autophagy-related ubiquitin-like modifier ATG8 |
| 免疫原 | E. coli - derived recombinant Magnaporthe oryzae ATG8 (Met1-Phe115). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | Q51MW4 |
| 背景信息 | Autophagy-related protein 8 (ATG8) is a ~14 kDa protein. Ubiquitin-like modifier involved in autophagosome formation. With ATG4, mediates the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Participates also in membrane fusion events that take place in the early secretory pathway. Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. |
| 备注 | For research use only |