当前位置:首页>产品中心>单抗/多抗>Anti-Mouse Serpinb1a Polyclonal Antibody|抗小鼠Serpinb1a多克隆抗体(靶标:小鼠丝氨酸蛋白酶抑制剂B1a)

Anti-Mouse Serpinb1a Polyclonal Antibody|抗小鼠Serpinb1a多克隆抗体(靶标:小鼠丝氨酸蛋白酶抑制剂B1a)

  • 货号:RB9TMD634014
  • 价格:面议
  • 点击:516
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产品介绍

产品参数

形态Liquid
宿主种属Rabbit
克隆性Polyclonal
抗体亚型IgG
纯化方式Purified by antigen affinity column.
内毒素水平Please contact with the lab for this information.
应用ELISA, IHC, WB
种属反应性Rat, Mouse
靶标Leukocyte elastase inhibitor A, Serine protease inhibitor EIA, Serpin B1a, Serpinb1, Serpinb1a
免疫原E. coli - derived recombinant Mouse Serpinb1a (Met1-Pro379).
储存缓冲液0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
产品使用说明ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000
登录号Q9D154
背景信息

Leukocyte elastase inhibitor A (Serpinb1a) is a ~42 kDa protein. Neutrophil serine protease inhibitor that plays an essential role in the regulation of the innate immune response, inflammation and cellular homeostasis. Acts primarily to protect the cell from proteases released in the cytoplasm during stress or infection. These proteases are important in killing microbes but when released from granules, these potent enzymes also destroy host proteins and contribute to mortality. Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3. Also acts as a potent intracellular inhibitor of granzyme H.

1. Benarafa, C. et al. (2007) The Journal of experimental medicine 204, 1901-9. PMID: 17664292
2. Benarafa, C. et al. (2011) Journal of leukocyte biology 90, 21-9. PMID: 21248149
3. Benarafa, C. (2011) Methods in enzymology 499, 135-48. PMID: 21683252
4. Choi, YJ. et al. (2019) Nature immunology 20, 276-287. PMID: 30692621
5. Benarafa, C. et al. (2002) The Journal of biological chemistry 277, 42028-33. PMID: 12189154
6. El Ouaamari, A. et al. (2016) Cell metabolism 23, 194-205. PMID: 26701651
备注For research use only
【仅供科学研究使用】

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