Anti-Rabbit IL1B/IL1F2 Polyclonal Antibody|抗兔IL1B/IL1F2多克隆抗体(靶标：兔白细胞介素1β/IL-1F2)
- 货号：RB9TTF943014
- 价格：面议
- 点击：438
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Oryctolagus cuniculus (Rabbit) |
| 靶标 | IL-1 beta, IL1B, Interleukin-1 beta, Lymphocyte proliferation-potentiating factor |
| 免疫原 | E. coli - derived recombinant Rabbit IL1B/IL1F2 (Ala117-Ser268). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | P14628 |
| 背景信息 | Interleukin-1 beta (IL1B/IL1F2) is a ~30 kDa protein. Potent pro-inflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6. IL1B is the therapeutic target of canakinumab (Ilaris). |
| 备注 | For research use only |
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