Anti-TRPV4 Polyclonal Antibody|抗TRPV4多克隆抗体(靶标：瞬时受体电位V型成员4)
- 货号：RB9THC206014
- 价格：面议
- 点击：454
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Human, Rat, Mouse |
| 靶标 | OTRPC4, Osm-9-like TRP channel 4, TRP12, TRPV4, Transient receptor potential cation channel subfamily V member 4, Transient receptor potential protein 12, TrpV4, VR-OAC, VRL-2, VRL2, VROAC, Vanilloid |
| 免疫原 | E. coli - derived recombinant TRPV4 (Arg151-Asn361). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 稳定性和储存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 重构方法 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 运输条件 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | Q9HBA0 |
| 观测分子量 | 100 kDa |
| 背景信息 | Transient receptor potential cation channel subfamily V member 4 (TRPV4) is a ~98 kDa protein. Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by heat, low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. 1. Arniges, M. et al. (2006) The Journal of biological chemistry 281, 1580-6. PMID: 16293632 2. Köttgen, M. et al. (2008) The Journal of cell biology 182, 437-47. PMID: 18695040 3. Garcia-Elias, A. et al. (2008) The Journal of biological chemistry 283, 31284-8. PMID: 18826956 4. Fiorillo, C. et al. (2012) Neurogenetics 13, 195-203. PMID: 22526352 5. Thorneloe, KS. et al. (2012) Science translational medicine 4, 159ra148. PMID: 23136043 6. Doñate-Macián, P. et al. (2018) Nature communications 9, 2307. PMID: 29899501 |
| 备注 | For research use only |
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