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Anti-Human DHH Polyclonal Antibody|抗人DHH多克隆抗体(靶标:人沙漠刺猬因子/Desert Hedgehog)

  • 货号:RB9THT127014
  • 价格:面议
  • 点击:316

产品介绍

产品参数

形态Liquid
宿主种属Rabbit
克隆性Polyclonal
抗体亚型IgG
纯化方式Purified by antigen affinity column.
内毒素水平Please contact with the lab for this information.
应用ELISA, IHC, WB
种属反应性Human, Mouse
靶标DHH, DHH-N, Desert hedgehog protein, Desert hedgehog protein N-product, EC:3.1.-.-, HHG-3
免疫原E. coli - derived recombinant Human DHH (Gly202-Gly396).
储存缓冲液0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
产品使用说明ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000
登录号O43323
背景信息

Desert hedgehog protein (DHH) is a ~43 kDa protein. The C-terminal part of the desert hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity. Both activities result in the cleavage of the full-length protein into two parts (N-product and C-product) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product (DHH-N). Both activities occur in the endoplasmic reticulum. Once cleaved, the C-product is degraded in the endoplasmic reticulum. Functions in cell-cell mediated juxtacrine signaling.

1. Pettigrew, CA. et al. (2014) Mechanisms of development 131, 137-49. PMID: 24342078
2. Hollier, PL. et al. (2021) Cardiovascular research 117, 2489-2501. PMID: 33063110
备注For research use only
【仅供科学研究使用】

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