Anti-Human TSPAN4 Polyclonal Antibody|抗人TSPAN4多克隆抗体(靶标：人四跨膜蛋白4/Tetraspanin-4)
- 货号：RB9THD423014
- 价格：面议
- 点击：516
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Mouse, Human |
| 靶标 | NAG-2, NAG2, Novel antigen 2, TM4SF7, TSPAN4, Tetraspanin-4, Transmembrane 4 superfamily member 7, Tspan-4 |
| 免疫原 | E. coli - derived recombinant Human TSPAN4 (Tyr107-Asn201). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | O14817 |
| 背景信息 | Tetraspanin-4 (TSPAN4) is a ~26 kDa protein. Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Plays an essential role in migrasome formation and migration on retracting fibers at the rear end of migrating cells. Migrasomes are cellular organelles that form as large vesicle-like structures on retraction fibers of migrating cells. Mechanistically, acts as a membrane curvature sensor and participates in stabilizing the migrasome structure in a late stage of biogenesis. May also play a regulatory role for the histamine H4 receptor/HRH4 without affecting histamine binding to HRH4 or signaling. 1. Huang, Y. et al. (2019) Nature cell biology 21, 991-1002. PMID: 31371828 2. Dharan, R. et al. (2022) Proceedings of the National Academy of Sciences of the United States of America 119, e2208993119. PMID: 36252000 3. Dharan, R. et al. (2023) Nature communications 14, 1037. PMID: 36823145 4. Ma, X. et al. (2021) Biomolecules 11. PMID: 34439793 |
| 备注 | For research use only |
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