Anti-Human TRIM72 Polyclonal Antibody|抗人TRIM72多克隆抗体(靶标：人三联基序蛋白72/MG53)
- 货号：RB9THD364014
- 价格：面议
- 点击：398
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Human |
| 靶标 | EC:2.3.2.27, MG53, Mg53, Mitsugumin-53, TRIM72, Tripartite motif-containing protein 72 |
| 免疫原 | E. coli - derived recombinant Human TRIM72 (Leu288-Ala477). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | Q6ZMU5 |
| 背景信息 | Tripartite motif-containing protein 72 (TRIM72) is a ~52 kDa protein. Muscle-specific E3 ubiquitin-protein ligase that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Its ubiquitination activity is mediated by E2 ubiquitin-conjugating enzymes UBE2D1, UBE2D2 and UBE2D3. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)-dependent membrane resealing process. 1. Ma, Y. et al. (2023) Nature communications 14, 1555. PMID: 36944613 |
| 备注 | For research use only |
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