Anti-Human ENPP7 Polyclonal Antibody|抗人ENPP7多克隆抗体(靶标：人外核苷酸焦磷酸酶/磷酸二酯酶7)
- 货号：RB9THD356014
- 价格：面议
- 点击：637
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Human |
| 靶标 | Alk-SMase, Alkaline sphingomyelin phosphodiesterase, E-NPP 7, EC:3.1.4.12, ENPP7, Ectonucleotide pyrophosphatase/phosphodiesterase family member 7, Intestinal alkaline sphingomyelinase, NPP-7 |
| 免疫原 | E. coli - derived recombinant Human ENPP7 (Asn31-Leu413). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | Q6UWV6 |
| 背景信息 | Ectonucleotide pyrophosphatase/phosphodiesterase family member 7 (ENPP7) is a ~51 kDa protein. Choline-specific phosphodiesterase that hydrolyzes sphingomyelin releasing the ceramide and phosphocholine and therefore is involved in sphingomyelin digestion, ceramide formation, and fatty acid (FA) absorption in the gastrointestinal tract. Also has phospholipase C activity and can also cleave phosphocholine from palmitoyl lyso-phosphatidylcholine and platelet-activating factor (PAF) leading to its inactivation. Does not have nucleotide pyrophosphatase activity. May promote cholesterol absorption by affecting the levels of sphingomyelin derived from either diet or endogenous sources, in the intestinal lumen. 1. Duan, RD. et al. (2003) Journal of lipid research 44, 1241-50. PMID: 12671034 2. Duan, RD. et al. (2003) The Journal of biological chemistry 278, 38528-36. PMID: 12885774 3. Wu, J. et al. (2004) American journal of physiology. Gastrointestinal and liver physiology 287, G967-73. PMID: 15205117 4. Wu, J. et al. (2006) The Biochemical journal 394, 299-308. PMID: 16255717 5. Gorelik, A. et al. (2017) The Journal of biological chemistry 292, 7087-7094. PMID: 28292932 |
| 备注 | For research use only |
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