| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Human, Mouse |
| 靶标 | SOS-2, SOS2, Son of sevenless homolog 2 |
| 免疫原 | E. coli - derived recombinant Human SOS2 (Met1-Asn561). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | Q07890 |
| 背景信息 | Son of sevenless homolog 2 (SOS2) is a ~152 kDa protein. Acts as guanine nucleotide exchange factor (GEF) for RAS proteins. Catalyzes the GDP-to-GTP exchange, resulting in an increase of the active GTP-bound form of HRAS. Acts as a key modulator of PI3K-AKT signaling. 1. Liu, AM. et al. (2010) Cellular signalling 22, 1448-58. PMID: 20639119 |
| 备注 | For research use only |