当前位置:首页>产品中心>单抗/多抗>Anti-Human DXO Polyclonal Antibody|抗人DXO多克隆抗体(靶标:人脱帽外切核酸酶/DXO)

Anti-Human DXO Polyclonal Antibody|抗人DXO多克隆抗体(靶标:人脱帽外切核酸酶/DXO)

  • 货号:RB9THD149014
  • 价格:面议
  • 点击:307

产品介绍

产品参数

形态Liquid
宿主种属Rabbit
克隆性Polyclonal
抗体亚型IgG
纯化方式Purified by antigen affinity column.
内毒素水平Please contact with the lab for this information.
应用ELISA, IHC, WB
种属反应性Human, Mouse, Rat
靶标5'-3' exoribonuclease DXO, DOM3L, DOM3Z, DXO, DeNADding enzyme DXO, Decapping and exoribonuclease protein, Dom-3 homolog Z, EC:3.1.13.-, EC:3.6.1.-, NAD-capped RNA hydrolase DXO, NG6
免疫原E. coli - derived recombinant Human DXO (Thr31-Lys396).
储存缓冲液0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
产品使用说明ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000
登录号O77932
背景信息

Decapping and exoribonuclease protein (DXO) is a ~44 kDa protein. Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA. The NAD-cap is present at the 5'-end of some RNAs and snoRNAs. In contrast to the canonical 5'-end N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay. Preferentially acts on NAD-capped transcripts in response to environmental stress. Also acts as a non-canonical decapping enzyme that removes the entire cap structure of m7G capped or incompletely capped RNAs and mediates their subsequent degradation.

1. Jiao, X. et al. (2017) Cell 168, 1015-1027.e10. PMID: 28283058
2. Grudzien-Nogalska, E. et al. (2019) Nature chemical biology 15, 575-582. PMID: 31101919
3. Picard-Jean, F. et al. (2018) PloS one 13, e0193804. PMID: 29601584
4. Doamekpor, SK. et al. (2020) Nucleic acids research 48, 6136-6148. PMID: 32374864
备注For research use only
【仅供科学研究使用】

相关产品:
总计 33037 个记录,共 1652 页,当前第 3 页 | 第一页 上一页 下一页 最末页
在线客服
  • 销售热线:
  • 15898894496(同微信)
  • 我要留言
  • 周一至周五每天9:00-17:00