Anti-Human FYN Polyclonal Antibody|抗人FYN多克隆抗体(靶标：人FYN原癌基因/Src家族酪氨酸激酶)
- 货号：RB9THC984014
- 价格：面议
- 点击：231
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Human, Mouse, Rat |
| 靶标 | EC:2.7.10.2, FYN, Proto-oncogene Syn, Proto-oncogene c-Fyn, SLK, Src-like kinase, Tyrosine-protein kinase Fyn, p59-Fyn |
| 免疫原 | E. coli - derived recombinant Human FYN (Thr85-Leu537). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | P06241 |
| 背景信息 | Tyrosine-protein kinase Fyn is a ~60 kDa protein. Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. 1. Wolf, RM. et al. (2001) Journal of neurobiology 49, 62-78. PMID: 11536198 2. Palacios, EH. et al. (2004) Oncogene 23, 7990-8000. PMID: 15489916 3. Meriane, M. et al. (2004) The Journal of cell biology 167, 687-98. PMID: 15557120 4. Yang, C. et al. (2006) Molecular cell 21, 135-41. PMID: 16387660 5. Goh, YM. et al. (2010) The Journal of biological chemistry 285, 10122-10129. PMID: 20100835 6. Raab, M. et al. (1995) Proceedings of the National Academy of Sciences of the United States of America 92, 8891-5. PMID: 7568038 7. Rigley, K. et al. (1995) Journal of immunology (Baltimore, Md. : 1950) 154, 1136-45. PMID: 7822789 8. Castaño, J. et al. (2007) Molecular and cellular biology 27, 1745-57. PMID: 17194753 |
| 备注 | For research use only |
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