Anti-Human S1PR1 Polyclonal Antibody|抗人S1PR1多克隆抗体(靶标：人鞘氨醇-1-磷酸受体1)
- 货号：RB9THC807014
- 价格：面议
- 点击：227
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Human, Mouse, Rat |
| 靶标 | CD363, CHEDG1, EDG1, Endothelial differentiation G-protein coupled receptor 1, S1P receptor 1, S1P receptor Edg-1, S1P1, S1PR1, Sphingosine 1-phosphate receptor 1, Sphingosine 1-phosphate receptor Edg |
| 免疫原 | E. coli - derived recombinant Human S1PR1 (Tyr311-Ser382). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | P21453 |
| 背景信息 | Sphingosine 1-phosphate receptor 1 (S1PR1) is a ~42 kDa protein. G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. |
| 备注 | For research use only |
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