Anti-Human CUL4A Polyclonal Antibody|抗人CUL4A多克隆抗体(靶标：人Cullin-RING泛素连接酶4A)
- 货号：RB9THC663024
- 价格：面议
- 点击：400
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Human, Mouse |
| 靶标 | CUL-4A, CUL4A, Cullin-4A |
| 免疫原 | E. coli - derived recombinant Human CUL4A (Gln570-Ala759). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | Q13619 |
| 背景信息 | Cullin-4A (CUL4A) is a ~87 kDa protein. Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN. 1. Higa, LA. et al. (2003) Nature cell biology 5, 1008-15. PMID: 14578910 2. Wertz, IE. et al. (2004) Science (New York, N.Y.) 303, 1371-4. PMID: 14739464 3. Hu, J. et al. (2004) Nature cell biology 6, 1003-9. PMID: 15448697 4. Nag, A. et al. (2004) Cancer research 64, 8152-5. PMID: 15548678 5. Matsuda, N. et al. (2005) DNA repair 4, 537-45. PMID: 15811626 6. Wang, H. et al. (2006) Molecular cell 22, 383-94. PMID: 16678110 7. Higa, LA. et al. (2006) Nature cell biology 8, 1277-83. PMID: 17041588 8. Han, J. et al. (2013) Cell 155, 817-29. PMID: 24209620 9. Chen, SH. et al. (2018) The EMBO journal 37. PMID: 30166453 10. Maiani, E. et al. (2021) Nature 592, 799-803. PMID: 33854232 |
| 备注 | For research use only |
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