Anti-Human GRB10 Polyclonal Antibody|抗人GRB10多克隆抗体(靶标：人生长因子受体结合蛋白10)
- 货号：RB9THC527014
- 价格：面议
- 点击：455
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Human |
| 靶标 | GRB10, GRB10 adapter protein, GRBIR, Growth factor receptor-bound protein 10, Insulin receptor-binding protein Grb-IR, KIAA0207 |
| 免疫原 | E. coli - derived recombinant Human GRB10 (Lys167-Leu417). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | Q13322 |
| 背景信息 | Growth factor receptor-bound protein 10 (GRB10) is a ~67 kDa protein. Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. |
| 备注 | For research use only |
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