Anti-Human HIPK2 Polyclonal Antibody|抗人HIPK2多克隆抗体(靶标：人同源域相互作用蛋白激酶2)
- 货号：RB9THC246014
- 价格：面议
- 点击：304
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Mouse, Rat, Human |
| 靶标 | EC:2.7.11.1, HIPK2, Homeodomain-interacting protein kinase 2, hHIPk2 |
| 免疫原 | E. coli - derived recombinant Human HIPK2 (Gln188-Arg553). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | Q9H2X6 |
| 背景信息 | Homeodomain-interacting protein kinase 2 (HIPK2) is a ~130 kDa protein. Serine/threonine-protein kinase involved in transcription regulation, p53/TP53-mediated cellular apoptosis and regulation of the cell cycle. Acts as a corepressor of several transcription factors, including SMAD1 and POU4F1/Brn3a and probably NK homeodomain transcription factors. Phosphorylates PDX1, ATF1, PML, p53/TP53, CREB1, CTBP1, CBX4, RUNX1, EP300, CTNNB1, HMGA1, ZBTB4 and DAZAP2. Inhibits cell growth and promotes apoptosis through the activation of p53/TP53 both at the transcription level and at the protein level (by phosphorylation and indirect acetylation). The phosphorylation of p53/TP53 may be mediated by a p53/TP53-HIPK2-AXIN1 complex. 1. Liebl, MC. et al. (2021) Nucleic acids research 49, 2759-2776. PMID: 33591310 |
| 备注 | For research use only |
相关产品:
| 产品名称 | 点击数 |
|---|---|
| 空肠弯曲菌单克隆抗体 | 7491 |
| 人触珠蛋白单克隆抗体 | 7677 |
| 贾第鞭毛虫单克隆抗体 | 7342 |
| 阿米巴单克隆抗体 | 7851 |
| 胃蛋白酶单克隆抗体 | 7372 |
| 胃蛋白酶原II单克隆抗体 | 7554 |
| 胃蛋白酶原I单克隆抗体 | 7287 |
| 艰难梭菌毒素A单克隆抗体 | 7434 |
| 艰难梭菌毒素B单克隆抗体 | 7732 |
| 艰难梭菌GDH单克隆抗体 | 7741 |
| 诺如病毒单克隆抗体 | 7230 |
| 伤寒沙门氏菌单克隆抗体 | 7307 |
| 鼠疫耶尔森菌F1单克隆抗体 | 6831 |
| 幽门螺杆菌单克隆抗体 | 7345 |
| 钙卫蛋白单克隆抗体 | 7134 |
| 乳铁蛋白单克隆抗体 | 7466 |
| 转铁蛋白单克隆抗体 | 7464 |
| 血红蛋白单克隆抗体 | 7200 |
| 腺病毒单克隆抗体 | 7415 |
| 轮状病毒单克隆抗体 | 7788 |