Anti-Human LIN28B Polyclonal Antibody|抗人LIN28B多克隆抗体(靶标：人LIN28B RNA结合蛋白)
- 货号：RB9THC186014
- 价格：面议
- 点击：250
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Mouse, Human |
| 靶标 | CSDD2, LIN28B, Lin-28B, Protein lin-28 homolog B |
| 免疫原 | E. coli - derived recombinant Human LIN28B (Gln26-Gly101). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | Q6ZN17 |
| 背景信息 | Protein lin-28 homolog B (LIN28B) is a ~27 kDa protein. Suppressor of microRNA (miRNA) biogenesis, including that of let-7 and possibly of miR107, miR-143 and miR-200c. Binds primary let-7 transcripts (pri-let-7), including pri-let-7g and pri-let-7a-1, and sequester them in the nucleolus, away from the microprocessor complex, hence preventing their processing into mature miRNA. Does not act on pri-miR21. The repression of let-7 expression is required for normal development and contributes to maintain the pluripotent state of embryonic stem cells by preventing let-7-mediated differentiation. When overexpressed, recruits ZCCHC11/TUT4 uridylyltransferase to pre-let-7 transcripts, leading to their terminal uridylation and degradation. 1. Piskounova, E. et al. (2011) Cell 147, 1066-79. PMID: 22118463 2. Heo, I. et al. (2009) Cell 138, 696-708. PMID: 19703396 |
| 备注 | For research use only |
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