Anti-Mouse PML Polyclonal Antibody|抗小鼠PML多克隆抗体(靶标：小鼠早幼粒细胞白血病蛋白)
- 货号：RB9TMB907014
- 价格：面议
- 点击：474
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Mouse |
| 靶标 | E3 SUMO-protein ligase PML, EC:2.3.2.-, MYL, PML, PP8675, Promyelocytic leukemia protein, Protein PML, RING finger protein 71, RING-type E3 SUMO transferase PML, RNF71, TRIM19, Tripartite motif-contai |
| 免疫原 | E. coli - derived recombinant Mouse PML (Arg618-Gly868). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | Q60953 |
| 背景信息 | Protein PML is a ~98 kDa protein. Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. Acts as the scaffold of PML-NBs allowing other proteins to shuttle in and out, a process which is regulated by SUMO-mediated modifications and interactions. Inhibits EIF4E-mediated mRNA nuclear export by reducing EIF4E affinity for the 5' 7-methylguanosine (m7G) cap of target mRNAs. Positively regulates p53/TP53 by acting at different levels (by promoting its acetylation and phosphorylation and by inhibiting its MDM2-dependent degradation). Regulates phosphorylation of ITPR3 and plays a role in the regulation of calcium homeostasis at the endoplasmic reticulum. |
| 备注 | For research use only |
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