当前位置:首页>产品中心>单抗/多抗>Anti-Human SLC5A1 Polyclonal Antibody|抗人SLC5A1多克隆抗体(靶标:人溶质载体家族5成员1/SGLT1)

Anti-Human SLC5A1 Polyclonal Antibody|抗人SLC5A1多克隆抗体(靶标:人溶质载体家族5成员1/SGLT1)

  • 货号:RB9THB272014
  • 价格:面议
  • 点击:630
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产品介绍

产品参数

形态Liquid
宿主种属Rabbit
克隆性Polyclonal
抗体亚型IgG
纯化方式Purified by antigen affinity column.
内毒素水平Please contact with the lab for this information.
应用ELISA, IHC, WB
种属反应性Homo sapiens (Human)
靶标High affinity sodium-glucose cotransporter, NAGT, Na(+)/glucose cotransporter 1, SGLT1, SLC5A1, Sodium/glucose cotransporter 1, Solute carrier family 5 member 1
免疫原E. coli - derived recombinant Human SLC5A1 (Asp230-Pro277&Ser335-Gly380&Arg564-Thr643).
储存缓冲液0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
产品使用说明ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000
登录号P13866
背景信息

Sodium/glucose cotransporter 1 (SLC5A1) is a ~73 kDa protein. Electrogenic Na(+)-coupled sugar symporter that actively transports D-glucose or D-galactose at the plasma membrane, with a Na(+) to sugar coupling ratio of 2:1. Transporter activity is driven by a transmembrane Na(+) electrochemical gradient set by the Na(+)/K(+) pump. Has a primary role in the transport of dietary monosaccharides from enterocytes to blood. Responsible for the absorption of D-glucose or D-galactose across the apical brush-border membrane of enterocytes, whereas basolateral exit is provided by GLUT2. Additionally, functions as a D-glucose sensor in enteroendocrine cells, triggering the secretion of the incretins GCG and GIP that control food intake and energy homeostasis.

1. Hummel, CS. et al. (2011) American journal of physiology. Cell physiology 300, C14-21. PMID: 20980548
2. Han, L. et al. (2022) Nature 601, 274-279. PMID: 34880492
3. Kamitori, K. et al. (2022) Journal of molecular biology 434, 167464. PMID: 35077764
4. Martín, MG. et al. (1996) Nature genetics 12, 216-20. PMID: 8563765
5. Cui, W. et al. (2023) Nature communications 14, 2920. PMID: 37217492
6. Salker, MS. et al. (2017) Scientific reports 7, 12612. PMID: 28974690
备注For research use only
【仅供科学研究使用】

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