当前位置：首页>产品中心>单抗/多抗>Anti-Tau (phosphe T217) Recombinant Antibody |抗Tau(磷酸化T217)重组抗体(靶标：磷酸化Tau(Thr217))
Anti-Tau (phosphe T217) Recombinant Antibody |抗Tau(磷酸化T217)重组抗体(靶标：磷酸化Tau(Thr217))
- 货号：RB9THY086273
- 价格：面议
- 点击：372
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Monoclonal |
| 抗体亚型 | IgG |
| 纯度 | >95% as determined by SDS-PAGE. |
| 纯化方式 | Protein A/G purified from cell culture supernatant. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, DB, IF |
| 种属反应性 | Homo sapiens (Human) |
| 靶标 | MAPT, MAPTL, MTBT1, Microtubule-associated protein tau, Neurofibrillary tangle protein, PHF-tau, Paired helical filament-tau, TAU |
| 储存缓冲液 | 0.01M PBS pH 7.4 |
| 稳定性和储存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 重构方法 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 登录号 | P10636 |
| 背景信息 | Microtubule-associated protein tau (Tau pT217) is a ~78 kDa protein. Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. 1. Yoshida, H. et al. (2012) Journal of neurochemistry 120, 165-76. PMID: 21985311 2. Sandberg, A. et al. (2020) Neurobiology of disease 146, 105079. PMID: 32961270 |
| 备注 | For research use only |
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