Anti-APLNR/APJ Polyclonal Antibody|抗APLNR/APJ多克隆抗体(靶标：爱帕琳肽受体/APJ)
- 货号：RB9THW667014
- 价格：面议
- 点击：456
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Homo sapiens (Human) |
| 靶标 | AGTRL1, APJ, APLNR, Angiotensin receptor-like 1, Apelin receptor, G-protein coupled receptor APJ, G-protein coupled receptor HG11 |
| 免疫原 | E. coli - derived recombinant APLNR/APJ (Glu2-Ser26&Leu167-Gly200&Tyr309-Asp380). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 稳定性和储存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 重构方法 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 运输条件 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | P35414 |
| 观测分子量 | 42 kDa |
| 背景信息 | Apelin receptor (APLNR/APJ) is a ~42 kDa protein. G protein-coupled receptor for peptide hormones apelin (APLN) and apelin receptor early endogenous ligand (APELA/ELA), that plays a role in the regulation of normal cardiovascular function and fluid homeostasis. When acting as apelin receptor, activates both G(i) protein pathway that inhibits adenylate cyclase activity, and the beta-arrestin pathway that promotes internalization of the receptor. APLNR/APJ also functions as mechanoreceptor that is activated by pathological stimuli in a G-protein-independent fashion to induce beta-arrestin signaling, hence eliciting cardiac hypertrophy. However, the presence of apelin ligand blunts cardiac hypertrophic induction from APLNR/APJ on response to pathological stimuli. Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a APELA receptor. 1. Cayabyab, M. et al. (2000) Journal of virology 74, 11972-6. PMID: 11090199 2. Scimia, MC. et al. (2012) Nature 488, 394-8. PMID: 22810587 3. Wang, Z. et al. (2015) Scientific reports 5, 8170. PMID: 25639753 4. Yang, P. et al. (2017) Circulation 135, 1160-1173. PMID: 28137936 5. Yue, Y. et al. (2022) Nature structural & molecular biology 29, 688-697. PMID: 35817871 6. Wang, WW. et al. (2024) Cell 187, 1460-1475.e20. PMID: 38428423 |
| 备注 | For research use only |
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