| 形态 | Liquid |
|---|---|
| 克隆性 | Monoclonal |
| 抗体亚型 | scFv-His |
| 纯度 | >95% as determined by SDS-PAGE. |
| 纯化方式 | Protein A/G purified from cell culture supernatant. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | Crystallography, Cryo-EM |
| 种属反应性 | Homo sapiens (Human) |
| 靶标 | Adenylate cyclase-stimulating G alpha protein, EC:3.6.5.-, GNAS, GNAS1, GSP, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short |
| 储存缓冲液 | 0.01M PBS pH 7.4 |
| 稳定性和储存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 重构方法 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 登录号 | P63092 |
| 背景信息 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short (Gαβγ) is a ~45 kDa protein. Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs). The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins. 1. Pak, Y. et al. (2002) Molecular and cellular biology 22, 7942-52. PMID: 12391161 2. Gao, X. et al. (2007) The Journal of biological chemistry 282, 294-302. PMID: 17110384 3. Thiele, S. et al. (2011) Human mutation 32, 653-60. PMID: 21488135 4. Brand, CS. et al. (2015) Molecular pharmacology 88, 758-67. PMID: 26206488 5. Farfel, Z. et al. (1996) The Journal of biological chemistry 271, 19653-5. PMID: 8702665 6. Warner, DR. et al. (1999) Proceedings of the National Academy of Sciences of the United States of America 96, 4268-72. PMID: 10200251 |
| 备注 | For research use only |
| 产品名称 | 点击数 |
|---|---|
| 倍硫磷单抗 | 6223 |
| 多菌灵/阿苯达唑二合一单抗 | 6262 |
| 三氯噻嗪单抗 | 6366 |
| 吡唑醚菌酯单抗 | 6565 |
| 烯酰吗啉单抗 | 6346 |
| 抑霉唑单抗 | 6110 |
| 恶醚唑(苯醚甲环唑)单抗 | 6299 |
| 赛拉嗪(甲苯噻嗪)单抗 | 6332 |
| 辛硫磷单抗 | 6369 |
| 多效唑单抗 | 6222 |
| 对硫磷单抗 | 6467 |
| 丙溴磷单抗 | 6452 |
| 戊唑醇单抗 | 6445 |
| 莠去津单抗 | 6371 |
| 灭蝇胺单抗 | 6074 |
| 尼卡巴嗪代谢物(DNC)单抗 | 6349 |
| 2.4-二氯苯氧乙酸单抗 | 6211 |
| 甲基对硫磷单抗 | 6305 |
| 左旋咪唑单抗 | 6219 |
| 三唑磷单抗 | 6287 |