Anti-Mouse PPARGC1A Polyclonal Antibody|抗小鼠PPARGC1A多克隆抗体(靶标：小鼠过氧化物酶体增殖物激活受体γ共激活因子1α/PGC-1α)
- 货号：RB9TMP446014
- 价格：面议
- 点击：850
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Rat, Human, Mouse |
| 靶标 | peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform b; Ppargc1a |
| 免疫原 | E. coli - derived recombinant Mouse PPARGC1A (Pro529-Arg797). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | O70343 |
| 背景信息 | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A) is a ~90 kDa protein. Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Acts as a key regulator of gluconeogenesis: stimulates hepatic gluconeogenesis by increasing the expression of gluconeogenic enzymes, and acting together with FOXO1 to promote the fasting gluconeogenic program. 1. Puigserver, P. et al. (2003) Nature 423, 550-5. PMID: 12754525 2. Rodgers, JT. et al. (2005) Nature 434, 113-8. PMID: 15744310 3. Ruas, JL. et al. (2012) Cell 151, 1319-31. PMID: 23217713 4. Puigserver, P. et al. (1998) Cell 92, 829-39. PMID: 9529258 |
| 备注 | For research use only |
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