当前位置：首页>产品中心>单抗/多抗>InVivoMAb anti-Mouse IL-6R alpha&IL6R Antibody|InVivoMAb抗小鼠IL-6Rα和IL6R抗体(靶标：小鼠白细胞介素6受体)
InVivoMAb anti-Mouse IL-6R alpha&IL6R Antibody|InVivoMAb抗小鼠IL-6Rα和IL6R抗体(靶标：小鼠白细胞介素6受体)
- 货号：RB9THY583010
- 价格：面议
- 点击：1004
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rat |
| 克隆性 | Monoclonal |
| 抗体亚型 | IgG2b, kappa |
| 纯度 | >95% as determined by SDS-PAGE. |
| 纯化方式 | Protein A/G purified from cell culture supernatant. |
| 内毒素水平 | < 10 EU/mg |
| 应用 | ELISA, FACS, Functional assay, Research in vivo |
| 种属反应性 | Mouse |
| 靶标 | Interleukin-6 receptor subunit alpha, IL-6 receptor subunit alpha, IL-6R subunit alpha, IL-6R-alpha, IL-6RA, IL-6R 1, Membrane glycoprotein 80, gp80, CD126, Soluble interleukin-6 receptor subunit alph |
| 储存缓冲液 | 0.01M PBS pH 7.4 |
| 稳定性和储存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. |
| 重构方法 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 产品使用说明 | ELISA: 1:2000-1:20000 |
| 登录号 | P08887 |
| 背景信息 | Interleukin-6 receptor subunit alpha (IL6R) is a ~51 kDa protein. Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation leads to the regulation of the immune response, acute-phase reactions and hematopoiesis. The interaction with membrane-bound IL6R and IL6ST stimulates 'classic signaling', the restricted expression of the IL6R limits classic IL6 signaling to only a few tissues such as the liver and some cells of the immune system. 1. Larsen, JV. et al. (2017) Molecular and cellular biology 37. PMID: 28265003 2. Kang, S. et al. (2019) Immunity 50, 1007-1023. PMID: 30995492 3. Spencer, S. et al. (2019) The Journal of experimental medicine 216, 1986-1998. PMID: 31235509 |
| 备注 | For research use only. |
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