Research Grade Elritercept|Elritercept（研究用级别）(靶标：Elritercept融合蛋白)
- 货号：RB9THB949026
- 价格：面议
- 点击：381
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Human |
| 克隆性 | Monoclonal |
| 抗体亚型 | Fusion-[human activin receptor type 2-A (activin r |
| 纯度 | >95% purity as determined by SDS-PAGE. |
| 纯化方式 | Purified by Nickel column. |
| 浓度 | 1mg/ml |
| 内毒素水平 | Please contact the lab for this information. |
| 应用 | ELISA, Functional assay, Research in vivo |
| 种属反应性 | Human |
| 靶标 | ACVR2, ACTRIIA, ACTR-IIA, Activin receptor type IIA, ACVR2A, Activin receptor type-2A |
| 储存缓冲液 | 0.01M PBS, pH 7.4. |
| 稳定性和储存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| 表达系统 | Mammalian Cells |
| 登录号 | P27037 |
| 背景信息 | Elritercept (KER-050) is a recombinant fusion protein comprising a modified activin receptor type IIA extracellular domain fused to a human IgG1 Fc. Elritercept inhibits activin A and other select TGF-β superfamily ligands. • Activin receptor type 2A (ACVR2A) functions directly in osteoblasts as a negative regulator of bone mass., PMID:28659341 • Activin a Receptor Type 2A Mutation Affects the Tumor Biology of Microsatellite Instability-High Gastric Cancer., PMID:33420656 • Endometrial receptivity and implantation require uterine BMP signaling through an ACVR2A-SMAD1/SMAD5 axis., PMID:34099644 • Gene expression and silencing of activin receptor type 2A (ACVR2A) in myoblast cells of chicken., PMID:27635666 • Type II BMP and activin receptors BMPR2 and ACVR2A share a conserved mode of growth factor recognition., PMID:35643319 • Murine FSH Production Depends on the Activin Type II Receptors ACVR2A and ACVR2B., PMID:32270195 • The m6A methyltransferase METTL3 regulates muscle maintenance and growth in mice., PMID:35013323 • Activin A/ACVR2A axis inhibits epithelial-to-mesenchymal transition in colon cancer by activating SMAD2., PMID:37378449 • Adenovirus‑mediated knockdown of activin A receptor type 2A attenuates immune‑induced hepatic fibrosis in mice and inhibits interleukin‑17‑induced activation of primary hepatic stellate cells., PMID:29620144 • A molecular study of synovial chondromatosis., PMID:31589790 |
| 别名 | 2727114-26-1 |
| 备注 | For research use only. Not suitable for clinical or therapeutic use. |
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