Research Grade Sifarobocept|Sifarobocept（研究用级别）(靶标：Sifarobocept融合蛋白)
- 货号：RB9THA097016
- 价格：面议
- 点击：498
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 抗体亚型 | Human ROBO2 fragment (1-203), fused to human IgG1 |
| 纯度 | >95% purity as determined by SDS-PAGE. |
| 纯化方式 | Protein A/G purified from cell culture supernatant. |
| 浓度 | 1mg/ml |
| 内毒素水平 | Please contact the lab for this information. |
| 应用 | ELISA, Functional assay, Research in vivo |
| 种属反应性 | Human |
| 靶标 | Roundabout homolog 2, KIAA1568, ROBO2 |
| 储存缓冲液 | 0.01M PBS, pH 7.4. |
| 稳定性和储存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| 表达系统 | Mammalian Cells |
| 登录号 | Q9HCK4 |
| 背景信息 | Sifarobocept is a recombinant fusion protein comprising an roundabout guidance receptor 2 (ROBO2) fused to a human IgG1 Fc. • Loss of Roundabout Guidance Receptor 2 (Robo2) in Podocytes Protects Adult Mice from Glomerular Injury by Maintaining Podocyte Foot Process Structure., PMID:32220420 • Conformational Change of the Hairpin-like-structured Robo2 Ectodomain Allows NELL1/2 Binding., PMID:35940226 • Robo2 contains a cryptic binding site for neural EGFL-like (NELL) protein 1/2., PMID:30700556 • Function of Slit/Robo signaling in breast cancer., PMID:26542734 • Genome-Wide Association Study Identifies ROBO2 as a Novel Susceptibility Gene for Anthracycline-Related Cardiomyopathy in Childhood Cancer Survivors., PMID:36508697 • Down-regulation of ROBO2 expression in prostate cancers., PMID:24272677 • Structural Principles in Robo Activation and Auto-inhibition., PMID:30853216 • ROBO2 hampers malignant biological behavior and predicts a better prognosis in pancreatic adenocarcinoma., PMID:34148491 • An ancient founder mutation located between ROBO1 and ROBO2 is responsible for increased microtia risk in Amerindigenous populations., PMID:35584116 • Alterations of ROBO1/DUTT1 and ROBO2 loci in early dysplastic lesions of head and neck: clinical and prognostic implications., PMID:19104841 |
| 别名 | 2760175-31-1 |
| 备注 | For research use only. Not suitable for clinical or therapeutic use. |
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