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Anti-Flu A (H3N2, RUO) HA/Hemagglutinin Broadly Neutralizing Reference Antibody|抗甲型流感（H3N2）HA/血凝素广谱中和参考抗体(靶标：甲型流感病毒H3N2血凝素)
- 货号：RB9TVK515096
- 价格：面议
- 点击：394
产品介绍
产品参数
| 产品描述 | CR8020 is a broadly neutralizing antibody (bNAb) targeting the stem region of influenza A virus (IAV) hemagglutinin (HA) and is in phase II trials for prophylactic use against group 2 IAVs. Structural and computational analyses show that CR8020 binds HA residues subject to antigenic drift and host selection pressure, with escape mutations observed in some H7N9 strains. Additionally, effective engagement of Fcγ receptors (FcγR) is crucial for antibody efficacy, but membrane steric hindrance may limit HA-CR8020-FcγR complex formation. These findings highlight epitope mutability and immune complex accessibility as key factors in bNAb development. |
|---|---|
| 形态 | Liquid |
| 宿主种属 | Human |
| 抗体亚型 | IgG1-lambda |
| 纯度 | >95% purity as determined by SDS-PAGE. |
| 纯化方式 | Protein A/G purified from cell culture supernatant. |
| 浓度 | 1mg/ml |
| 内毒素水平 | Please contact the lab for this information. |
| 应用 | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
| 种属反应性 | Influenza A virus (strain A/Hong Kong/1/1968 H3N2) |
| 靶标 | Hemagglutinin, Hemagglutinin HA1 chain, Hemagglutinin HA2 chain, HA |
| 储存缓冲液 | 0.01M PBS, pH 7.4. |
| 稳定性和储存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| 表达系统 | Mammalian Cells |
| 登录号 | Q91MA7 |
| 备注 | For research use only. Not suitable for clinical or therapeutic use. |
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