当前位置：首页>产品中心>单抗/多抗>InVivo Plus Mouse PD-1 Antibody(RMP1-14)|InVivo Plus小鼠PD-1抗体(靶标：小鼠程序性细胞死亡蛋白1/PD-1)
InVivo Plus Mouse PD-1 Antibody(RMP1-14)|InVivo Plus小鼠PD-1抗体(靶标：小鼠程序性细胞死亡蛋白1/PD-1)
- 货号：RB9TMS870039
- 价格：面议
- 点击：386
产品介绍
产品参数
| 产品描述 | The RMP1-14 monoclonal antibody recognizes mouse PD-1 (CD279), a 50–55 kDa CD28-family receptor transiently expressed on thymocytes, activated T and B cells, and myeloid cells. PD-1 contains an ITIM motif and delivers inhibitory signals upon engagement with its ligands PD-L1 and PD-L2, reducing T-cell activation and promoting peripheral tolerance. PD-1 deficiency in mice leads to autoimmunity, while PD-L1 upregulation in tumors enhances resistance to CD8 T-cell–mediated killing. Blocking the PD-1/PD-L1 pathway can inhibit tumor growth in mouse models. RMP1-14, like J43, effectively blocks PD-1 binding to both PD-L1 and PD-L2. |
|---|---|
| 形态 | Liquid |
| 宿主种属 | Rat |
| 克隆性 | Monoclonal |
| 抗体亚型 | IgG2a, kappa |
| 纯度 | >95% as determined by SDS-PAGE. |
| 纯化方式 | Protein A/G purified from cell culture supernatant. |
| 内毒素水平 | <1 EU/mg |
| 应用 | in vivo blocking of PD-1/PD-L signaling |
| 种属反应性 | Mouse |
| 靶标 | Programmed cell death protein 1, Protein PD-1, mPD-1, CD279, Pdcd1, Pd1 |
| 储存缓冲液 | 0.01M PBS, pH 7.4. |
| 稳定性和储存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 登录号 | Q02242 |
| 备注 | For research use only. |
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