当前位置：首页>产品中心>单抗/多抗>InVivo Plus Mouse PD-1 Antibody(RMP1-14)|InVivo Plus小鼠PD-1抗体(靶标：小鼠程序性细胞死亡蛋白1/PD-1)

InVivo Plus Mouse PD-1 Antibody(RMP1-14)|InVivo Plus小鼠PD-1抗体(靶标：小鼠程序性细胞死亡蛋白1/PD-1)

产品描述	The RMP1-14 monoclonal antibody recognizes mouse PD-1 (CD279), a 50–55 kDa CD28-family receptor transiently expressed on thymocytes, activated T and B cells, and myeloid cells. PD-1 contains an ITIM motif and delivers inhibitory signals upon engagement with its ligands PD-L1 and PD-L2, reducing T-cell activation and promoting peripheral tolerance. PD-1 deficiency in mice leads to autoimmunity, while PD-L1 upregulation in tumors enhances resistance to CD8 T-cell–mediated killing. Blocking the PD-1/PD-L1 pathway can inhibit tumor growth in mouse models. RMP1-14, like J43, effectively blocks PD-1 binding to both PD-L1 and PD-L2.
形态	Liquid
宿主种属	Rat
克隆性	Monoclonal
抗体亚型	IgG2a, kappa
纯度	>95% as determined by SDS-PAGE.
纯化方式	Protein A/G purified from cell culture supernatant.
内毒素水平	<1 EU/mg
应用	in vivo blocking of PD-1/PD-L signaling
种属反应性	Mouse
靶标	Programmed cell death protein 1, Protein PD-1, mPD-1, CD279, Pdcd1, Pd1
储存缓冲液	0.01M PBS, pH 7.4.
稳定性和储存	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
登录号	Q02242
备注	For research use only.

【仅供科学研究使用】

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