当前位置:首页>产品中心>单抗/多抗>Anti-Yersinia pestis Plasminogen activator/Pla Polyclonal Antibody|抗鼠疫耶尔森菌纤溶酶原激活物/Pla多克隆抗体(靶标:鼠疫耶尔森菌纤溶酶原激活物)

Anti-Yersinia pestis Plasminogen activator/Pla Polyclonal Antibody|抗鼠疫耶尔森菌纤溶酶原激活物/Pla多克隆抗体(靶标:鼠疫耶尔森菌纤溶酶原激活物)

  • 货号:RB9TJN173024
  • 价格:面议
  • 点击:378
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产品介绍

产品参数

形态Liquid
宿主种属Rabbit
克隆性Polyclonal
抗体亚型IgG
纯化方式Purified by antigen affinity column.
内毒素水平Please contact with the lab for this information.
应用ELISA, IHC, WB
种属反应性Yersinia pestis
靶标Coagulase/fibrinolysin, EC:3.4.23.48, Pla, Plasminogen activator, pla
免疫原E. coli - derived recombinant Yersinia pestis Plasminogen activator/Pla (Ala21-Phe312).
储存缓冲液0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
产品使用说明ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000
登录号P17811
背景信息

Plasminogen activator is a ~34 kDa protein. In the mammalian host activates (cleaves) plasminogen to generate the serine protease plasmin. Plasmin degrades fibrin clots (fibrinolysis) and facilitates bacterial cell migration, enabling rapid dissemination of bacteria from the initial site of infection (Probable). Cleaves host plasminogen to generate plasmin and probably also has autocatalytic activity. Fibrinolytic activity prevails at 37 degrees Celsius whereas coagulase expression predominates at lower temperatures (28 degrees Celsius). Cleaves plasminogen; plasminogen cleavage is much higher than coagulase activity.

1. Eren, E. et al. (2010) Structure (London, England : 1993) 18, 809-18. PMID: 20637417
2. Eren, E. et al. (2012) The Journal of biological chemistry 287, 23971-6. PMID: 22645135
3. McDonough, KA. et al. (1989) Molecular microbiology 3, 767-75. PMID: 2526282
4. Sodeinde, OA. et al. (1989) Infection and immunity 57, 1517-23. PMID: 2651310
备注For research use only
【仅供科学研究使用】

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