Anti-Human PIP4K2A Polyclonal Antibody|抗人PIP4K2A多克隆抗体(靶标：人磷脂酰肌醇-5-磷酸4-激酶2A型)
- 货号：RB9THD637014
- 价格：面议
- 点击：516
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Human, Rat, Mouse |
| 靶标 | 1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha, Diphosphoinositide kinase 2-alpha, EC:2.7.1.149, PI(5)P 4-kinase type II alpha, PI5P4KA, PI5P4Kalpha, PIP4K2A, PIP4KII-alpha, PIP5K2, PIP5K2A, PIP5 |
| 免疫原 | E. coli - derived recombinant Human PIP4K2A (Ser34-Thr406). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | P48426 |
| 背景信息 | Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (PIP4K2A) is a ~46 kDa protein. Catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Has both ATP- and GTP-dependent kinase activities. May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation. Required for lysosome-peroxisome membrane contacts and intracellular cholesterol transport through modulating peroxisomal PtdIns(4,5)P2 level. 1. Davis, MI. et al. (2013) PloS one 8, e54127. PMID: 23326584 2. Rameh, LE. et al. (1997) Nature 390, 192-6. PMID: 9367159 3. Sumita, K. et al. (2016) Molecular cell 61, 187-98. PMID: 26774281 4. Wilcox, A. et al. (2008) FEBS letters 582, 1391-4. PMID: 18364242 5. Hu, A. et al. (2018) Journal of lipid research 59, 507-514. PMID: 29353240 6. Wang, DG. et al. (2019) Cell reports 27, 1991-2001.e5. PMID: 31091439 |
| 备注 | For research use only |
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