Anti-Human RCC1 Polyclonal Antibody|抗人RCC1多克隆抗体(靶标：人染色体浓缩调节蛋白1)
- 货号：RB9THD651014
- 价格：面议
- 点击：509
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Mouse, Human |
| 靶标 | CHC1, Cell cycle regulatory protein, Chromosome condensation protein 1, RCC1, Regulator of chromosome condensation |
| 免疫原 | E. coli - derived recombinant Human RCC1 (Val37-Ser421). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | P18754 |
| 背景信息 | Regulator of chromosome condensation (RCC1) is a ~44 kDa protein. Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP, and thereby plays an important role in RAN-mediated functions in nuclear import and mitosis. Contributes to the generation of high levels of chromosome-associated, GTP-bound RAN, which is important for mitotic spindle assembly and normal progress through mitosis. Via its role in maintaining high levels of GTP-bound RAN in the nucleus, contributes to the release of cargo proteins from importins after nuclear import. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA. 1. Renault, L. et al. (2001) Cell 105, 245-55. PMID: 11336674 2. Chen, T. et al. (2007) Nature cell biology 9, 596-603. PMID: 17435751 3. Bischoff, FR. et al. (1991) Nature 354, 80-2. PMID: 1944575 4. Tooley, CE. et al. (2010) Nature 466, 1125-8. PMID: 20668449 5. Halpin, D. et al. (2011) PLoS biology 9, e1001225. PMID: 22215983 6. Sankhala, RS. et al. (2017) Nature communications 8, 979. PMID: 29042532 7. Moore, W. et al. (2002) Current biology : CB 12, 1442-7. PMID: 12194828 |
| 备注 | For research use only |
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