| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Mouse, Human |
| 靶标 | FMN2, Formin-2 |
| 免疫原 | E. coli - derived recombinant Human FMN2 (Ser1361-Thr1722). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | Q9NZ56 |
| 背景信息 | Formin-2 (FMN2) is a ~180 kDa protein. Actin-binding protein that is involved in actin cytoskeleton assembly and reorganization. Acts as an actin nucleation factor and promotes assembly of actin filaments together with SPIRE1 and SPIRE2. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning, asymmetric oocyte division and polar body extrusion during female germ cell meiosis. Plays a role in responses to DNA damage, cellular stress and hypoxia by protecting CDKN1A against degradation, and thereby plays a role in stress-induced cell cycle arrest. 1. Vizcarra, CL. et al. (2011) Proceedings of the National Academy of Sciences of the United States of America 108, 11884-9. PMID: 21730168 2. Peng, KW. et al. (2012) Biochimica et biophysica acta 1820, 469-81. PMID: 22330775 3. Yamada, K. et al. (2013) Molecular cell 49, 922-33. PMID: 23375502 4. Belin, BJ. et al. (2015) eLife 4, e07735. PMID: 26287480 |
| 备注 | For research use only |
| 产品名称 | 点击数 |
|---|---|
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| 阿米巴单克隆抗体 | 7924 |
| 胃蛋白酶单克隆抗体 | 7415 |
| 胃蛋白酶原II单克隆抗体 | 7626 |
| 胃蛋白酶原I单克隆抗体 | 7335 |
| 艰难梭菌毒素A单克隆抗体 | 7506 |
| 艰难梭菌毒素B单克隆抗体 | 7798 |
| 艰难梭菌GDH单克隆抗体 | 7787 |
| 诺如病毒单克隆抗体 | 7280 |
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| 鼠疫耶尔森菌F1单克隆抗体 | 6879 |
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| 乳铁蛋白单克隆抗体 | 7524 |
| 转铁蛋白单克隆抗体 | 7525 |
| 血红蛋白单克隆抗体 | 7243 |
| 腺病毒单克隆抗体 | 7464 |
| 轮状病毒单克隆抗体 | 7856 |