当前位置:首页>产品中心>单抗/多抗>Anti-Human SLCO1A2 Polyclonal Antibody|抗人SLCO1A2多克隆抗体(靶标:人溶质载体有机阴离子转运蛋白家族1A2)

Anti-Human SLCO1A2 Polyclonal Antibody|抗人SLCO1A2多克隆抗体(靶标:人溶质载体有机阴离子转运蛋白家族1A2)

  • 货号:RB9THW453014
  • 价格:面议
  • 点击:570
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产品介绍

产品参数

形态Liquid
宿主种属Rabbit
克隆性Polyclonal
抗体亚型IgG
纯化方式Purified by antigen affinity column.
内毒素水平Please contact with the lab for this information.
应用ELISA, IHC, WB
种属反应性Human
靶标OATP, OATP-1, OATP-A, OATP1, OATP1A2, Organic anion-transporting polypeptide 1, SLC21A3, SLCO1A2, Sodium-independent organic anion transporter, Solute carrier family 21 member 3, Solute carrier organi
免疫原E. coli - derived recombinant Human SLCO1A2 (Phe406-Phe513).
储存缓冲液0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
产品使用说明ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000
登录号P46721
背景信息

Solute carrier organic anion transporter family member 1A2 (SLCO1A2) is a ~74 kDa protein. Na(+)-independent transporter that mediates the cellular uptake of a broad range of organic anions such as the endogenous bile salts cholate and deoxycholate, either in their unconjugated or conjugated forms (taurocholate and glycocholate), at the plasmam membrane. Responsible for intestinal absorption of bile acids. Transports dehydroepiandrosterone 3-sulfate (DHEAS), a major circulating steroid secreted by the adrenal cortex, as well as estrone 3-sulfate and 17beta-estradiol 17-O-(beta-D-glucuronate). Mediates apical uptake of all-trans-retinol (atROL) across human retinal pigment epithelium, which is essential to maintaining the integrity of the visual cycle and thus vision. Involved in the uptake of clinically used drugs.

1. Leuthold, S. et al. (2009) American journal of physiology. Cell physiology 296, C570-82. PMID: 19129463
2. Kullak-Ublick, GA. et al. (1995) Gastroenterology 109, 1274-82. PMID: 7557095
3. Kullak-Ublick, GA. et al. (2001) Gastroenterology 120, 525-33. PMID: 11159893
4. Briz, O. et al. (2003) The Biochemical journal 371, 897-905. PMID: 12568656
5. Zhou, F. et al. (2013) The AAPS journal 15, 1099-108. PMID: 23918469
6. Chan, T. et al. (2015) British journal of pharmacology 172, 2343-53. PMID: 25560245
7. Kullak-Ublick, GA. et al. (1998) FEBS letters 424, 173-6. PMID: 9539145
8. Bailey, DG. et al. (2007) Clinical pharmacology and therapeutics 81, 495-502. PMID: 17301733
备注For research use only
【仅供科学研究使用】

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