当前位置:首页>产品中心>单抗/多抗>Anti-LCMV RdRp/Protein L Polyclonal Antibody|抗LCMV RdRp/蛋白L多克隆抗体(靶标:淋巴细胞性脉络丛脑膜炎病毒RNA聚合酶大亚基)

Anti-LCMV RdRp/Protein L Polyclonal Antibody|抗LCMV RdRp/蛋白L多克隆抗体(靶标:淋巴细胞性脉络丛脑膜炎病毒RNA聚合酶大亚基)

  • 货号:RB9TVK147014
  • 价格:面议
  • 点击:226

产品介绍

产品参数

形态Liquid
宿主种属Rabbit
克隆性Polyclonal
抗体亚型IgG
纯化方式Purified by antigen affinity column.
内毒素水平Please contact with the lab for this information.
应用ELISA, IHC, WB
种属反应性Lymphocytic choriomeningitis virus
靶标EC:2.7.7.48, EC:3.1.-.-, L, Large structural protein, Protein L, RNA-directed RNA polymerase L, Replicase, Transcriptase, cap-snatching endonuclease
免疫原E. coli - derived recombinant LCMV RdRp/Protein L (Asp2-Lys196).
储存缓冲液0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
产品使用说明ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000
登录号P14240
背景信息

RNA-directed RNA polymerase L (RdRp/Protein L) is a ~254 kDa protein. RNA-dependent RNA polymerase, which is responsible for the replication and transcription of the viral RNA genome using antigenomic RNA as an intermediate. During transcription, synthesizes subgenomic RNAs and assures their capping by a cap-snatching mechanism, which involves the endonuclease activity cleaving the host capped pre-mRNAs. These short capped RNAs are then used as primers for viral transcription. The 3'-end of subgenomic mRNAs molecules are heterogeneous and not polyadenylated. The replicase function is to direct synthesis of antigenomic and genomic RNA which are encapsidated and non capped.

1. Liu, L. et al. (2023) Protein & cell 14, 703-707. PMID: 37038286
备注For research use only
【仅供科学研究使用】

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